FcRI在溃疡性结肠炎复发患者中起关键 - 结肠溃疡病

TUhjnbcbe - 2020/11/29 6:42:00

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FcγRIplaysacriticalroleinpatientswithulcerativecolitisrelapse.

FcγRI在溃疡性结肠炎复发患者中起关键作用

Abstract

Ulcerativecolitis(UC)isadiseasethatfrequentlyrelapsesandaffectsmorethan0.1%generalpopulation;theunderlyingmechanismispoorlyunderstood.Publisheddatashowthatpolymorphonuclearneutrophils(PMN)contributetothepathogenesisofUC.Thisstudyaimstoidentifyantigen(Ag)-specificPMNsandinvestigatetheirroleinUCrelapse.Inthisstudy,thecorrelationbetweenPMNactivitiesandUCrelapsewasassessedinagroupofUCpatients.AUCmousemodelwasdevelopedtoexpandthefindingsofUCpatientstudy.

TheresultsshowedthatapositivecorrelationwasdetectedbetweenthehighPMNactivitiesandthefoodAg-specificIgG(sIgG)amountsincolonbiopsiesofUCpatients.UCpatient-derivedAg-specificPMNscouldbeactivateduponexposuretofoodspecificAg(sAg).TheAg/FcγRI

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